Potassium Carbonate → HCID 21882971, compound

HRID 722089Notes

Reaction equation

[Cl:1][C:2]1[N:10]=[C:9]([NH2:11])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:12][C:13]1[CH:14]=[N:15][C:16]([CH3:28])=[C:17]([O:24]C(=O)C)[C:18]=1[CH2:19][O:20]C(=O)C.C([O-])([O-])=O.[K+].[K+]>CO>[Cl:1][C:2]1[N:10]=[C:9]([NH2:11])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:12][C:13]1[CH:14]=[N:15][C:16]([CH3:28])=[C:17]([OH:24])[C:18]=1[CH2:19][OH:20]

Participants

Conditions

Temperature: 50 °C

Procedure

A suspension of 6-chloro-9-(5-acetoxy-4-acetoxymethyl-6-methyl-pyridin-3-ylmethyl)-9H-purin-2-ylamine and K2CO3 (excess) in MeOH was heated to 50° C. for 15 min. Filtration, work-up (EtOAc) and purification by preparative TLC gave the title compound. HPLC Rt: 4.498 min. 1H-NMR (d6-DMSO) δ 8.08 (s, 1H), 7.74 (s, 1H), 6.95 (s, 1H), 5.31 (s, 2H), 4.74 (s, 2H), 2.31 (s, 3H).

Workup

filtrationFiltration, work-up (EtOAc) and purification by preparative TLC

Sources & evidence

ORD record: ord-1849f39cab224590af86f699f10258f9
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138401B2

Reaction notes

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