O-Methylhydroxylamine hydrochloride → 9-(3-Chloro-2,6-difluorobenzyl)-N-methoxy-9H-beta-carboline-3-carboxamide

HRID 722128Notes

Reaction equation

HRID 722128 reaction equation
[Cl:1][C:2]1[C:3]([F:26])=[C:4]([C:22]([F:25])=[CH:23][CH:24]=1)[CH2:5][N:6]1[C:18]2[CH:17]=[N:16][C:15]([C:19](O)=[O:20])=[CH:14][C:13]=2[C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2.Cl.[CH3:28][O:29][NH2:30]>>[Cl:1][C:2]1[C:3]([F:26])=[C:4]([C:22]([F:25])=[CH:23][CH:24]=1)[CH2:5][N:6]1[C:18]2[CH:17]=[N:16][C:15]([C:19]([NH:30][O:29][CH3:28])=[O:20])=[CH:14][C:13]=2[C:12]2[C:7]1=[CH:8][CH:9]=[CH:10][CH:11]=2

Participants

3

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 218833949-(3-chloro-2,6-difluorobenzyl)-9H-beta-carboline-3-carboxylic acid

Product 1

HCID 100466409-(3-Chloro-2,6-difluorobenzyl)-N-methoxy-9H-beta-carboline-3-carboxamide

Procedure

The title compound is prepared by coupling of 9-(3-chloro-2,6-difluorobenzyl)-9H-β-carboline-3-carboxylic acid and O-methyl hydroxylamine hydrochloride under conditions similar to those provided in step (b) of example 7.

Workup

  1. customthose provided in step (b) of example 7

Sources & evidence

ORD record
ord-a04da0cf29f6400cad1addd382fcd340
Source dataset
uspto-grants-2006_11
Patent number
US07138408B2

Reaction notes

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