Lithium Hydroxide → HCID 68976148, compound

HRID 72213Notes

Reaction equation

HRID 72213 reaction equation
[Li+].[OH-].C[O:4][C:5]([C:7]1[S:15][C:14]2[C:13](=[O:16])[N:12]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH2:29][CH2:28][CH2:27][N:26]([CH3:30])[CH2:25][CH2:24]4)=[CH:19][CH:18]=3)[CH:11]=[N:10][C:9]=2[CH:8]=1)=[O:6]>C1COCC1.O>[CH3:30][N:26]1[CH2:27][CH2:28][CH2:29][N:23]([C:20]2[CH:21]=[CH:22][C:17]([N:12]3[C:13](=[O:16])[C:14]4[S:15][C:7]([C:5]([OH:6])=[O:4])=[CH:8][C:9]=4[N:10]=[CH:11]3)=[CH:18][CH:19]=2)[CH2:24][CH2:25]1

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 68976146HCID 68976146, compound

Product 1

HCID 68976148HCID 68976148, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A 2M LiOH solution (1.2 mL) was added to a solution of 3-[4-(4-methylperhydro-1,4-diazepin-1-yl)phenyl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-6-carboxylic acid methyl ester (477.8 mg) in THF (5 mL) and water (5 mL), and the mixture was stirred at room temperature for 5 h. The solvent was then removed in vacuo and the crude product was purified by preparative HPLC. The product with the molecular weight of 384.45 (C19H20N4O3S) was obtained in this way; MS (ESI): 385 (M+H+).

Workup

  1. customThe solvent was then removed in vacuo
  2. customthe crude product was purified by preparative HPLC
  3. customThe product with the molecular weight of 384.45 (C19H20N4O3S) was obtained in this way

Sources & evidence

ORD record
ord-f83e73242d024654b1f83e786e2f34cf
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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