Water → HCID 21883624, compound

A mixture of 3-bromo-5-chlorosalicylaldehyde (1.9 g, 4.2 mmol), potassium carbonate (0.58 g, 4.2 mmol), and ethyl 4,4,4-trifluorocrotonate (0.79 g, 4.7 mmol) was stirred in N,N-dimethylformamide (5 mL) at 95° C. for 18 h. Water (100 mL) was added and the mixture was extracted with ether (3×50 mL). The combined organic extracts were washed with sodium hydroxide (10 mL) and water (2×50 mL). After drying over MgSO4 and concentrating, the mixture filtered through of a pad of silica eluting with ethyl acetate-hexanes (1:4). The eluant was concentrated and a light yellow solid was crystallized from cold hexane (0.43 g, 26%): mp 101.0–102.2° C. 1H NMR (acetone-d6/300 MHz) 7.90 (s, 1H), 7.65 (d, H, J=2.4 Hz), 7.61 (d, H, J=2.4 Hz), 6.03 (qH-F, 1H, J=6.9 Hz), 4.34 (m, 2H), 1.33 (t, 3H, J=7.5 Hz). ESHRMS m/z 384.9435 (M−H, Calc'd 384.9454). Anal. Calc'd for C13H9BrClF3O3: C, 40.50; H, 2.35. Found: C, 40.61; H, 2.40.

1. extractionthe mixture was extracted with ether (3×50 mL)
2. washThe combined organic extracts were washed with sodium hydroxide (10 mL) and water (2×50 mL)
3. dry with materialAfter drying over MgSO4
4. concentrationconcentrating
5. filtrationthe mixture filtered through of a pad of silica eluting with ethyl acetate-hexanes (1:4)
6. concentrationThe eluant was concentrated
7. customa light yellow solid was crystallized from cold hexane (0.43 g, 26%)

ORD record

ord-545de35fde2d4864a6993b24b51612d5

Source dataset

uspto-grants-2006_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07138411B2