p-Toluenesulfonic acid → 3-[4-(4-Methyl[1,4]diazepan-1-yl)phenyl]-6-(2-methylpropenyl)-3H-thieno[3,2-d]pyrimidin-4-one

HRID 72235Notes

Reaction equation

HRID 72235 reaction equation
O[CH:2]([C:6]1[S:14][C:13]2[C:12](=[O:15])[N:11]([C:16]3[CH:21]=[CH:20][C:19]([N:22]4[CH2:28][CH2:27][CH2:26][N:25]([CH3:29])[CH2:24][CH2:23]4)=[CH:18][CH:17]=3)[CH:10]=[N:9][C:8]=2[CH:7]=1)[CH:3]([CH3:5])[CH3:4].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[CH3:29][N:25]1[CH2:26][CH2:27][CH2:28][N:22]([C:19]2[CH:18]=[CH:17][C:16]([N:11]3[C:12](=[O:15])[C:13]4[S:14][C:6]([CH:2]=[C:3]([CH3:5])[CH3:4])=[CH:7][C:8]=4[N:9]=[CH:10]3)=[CH:21][CH:20]=2)[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 24859708HCID 24859708, compound

Product 1

HCID 248598463-[4-(4-Methyl[1,4]diazepan-1-yl)phenyl]-6-(2-methylpropenyl)-3H-thieno[3,2-d]pyrimidin-4-one

Procedure

6-(1-Hydroxy-2-methylpropyl)-3-[4-(4-methyl[1,4]diazepan-1-yl)phenyl]-3H-thieno[3,2-d]pyrimidin-4-one and p-toluenesulfonic acid were reacted by method AA. The crude product was purified by preparative HPLC. The product with the molecular weight of 394.54 (C22H26N4OS) was obtained in this way; MS (ESI): 395 (M+H+).

Workup

  1. customThe crude product was purified by preparative HPLC
  2. customThe product with the molecular weight of 394.54 (C22H26N4OS) was obtained in this way

Sources & evidence

ORD record
ord-83be697aa64b478d8d28e3e38497437c
Source dataset
uspto-grants-2014_09
Patent number
US08828991B2

Reaction notes

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