Salicylaldehyde → 2-Hydroxy-4-(2-hydroxy-1,1-dimethylethyl)benzaldehyde

HRID 722361Notes

Reaction equation

[OH:1][CH2:2][C:3]([C:6]1[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=1)([CH3:5])[CH3:4].C(=O)C1[C:15](=CC=CC=1)[OH:16]>>[OH:1][CH2:2][C:3]([C:6]1[CH:7]=[C:8]([OH:12])[C:9](=[CH:10][CH:11]=1)[CH:15]=[O:16])([CH3:5])[CH3:4]

Participants

Reactant 2

HCID 6998Salicylaldehyde

HCID 21883735HCID 21883735, compound

Product 1

HCID 218837242-Hydroxy-4-(2-hydroxy-1,1-dimethylethyl)benzaldehyde

Procedure

The phenol (Step 5) was converted to the salicylaldehyde via a method similar to that described in Example 2, Step 1: mp 80.4–81.9° C. 1H NMR (CDCl3/300 MHz) 11.00 (s, 1H), 9.87 (s, 1H), 7.51 (d, 1H, J=8.3 Hz), 7.08 (dd, 1H, J=8.3 Hz, 1.4 Hz), 7.02 (d, 1H, J=1.4 Hz), 3.66 (s, 2H), 1.34 (s, 6H).

Sources & evidence

ORD record: ord-0b89d4aeaa2f4dd190a8241edc60d842
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138411B2

Reaction notes

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