Hydrochloric Acid → HCID 87900553, compound

HRID 722397Notes

Reaction equation

HRID 722397 reaction equation
C(OC([N:8]1[CH2:12][C@@H:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C@H:10]([CH2:19][O:20][C:21]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=2)[CH2:9]1)=O)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].Cl>CO>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[F:33][C:31]([F:32])([F:34])[C:23]1[CH:22]=[C:21]([CH:26]=[C:25]([C:27]([F:30])([F:28])[F:29])[CH:24]=1)[O:20][CH2:19][C@H:10]1[C@H:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:12][NH:8][CH2:9]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6422Trifluoroacetic acidHCID 131726065HCID 131726065, compound

Product 1

HCID 87900553HCID 87900553, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The mixture of trans-tert-butyl-3-((3,5-bis(trifluoromethyl)phenoxy)methyl)-4-phenylpyrrolidine-1-carboxylate as trifluoroacetic acid salt (31 mg) and HCl (1.0 M diethyl ether solution, 0.5 mL) in methanol (0.2 mL) was stirred at room temperature over night. The reaction mixture was concentrated under vacuum and purified by preparative HPLC to yield a white solid as the title compound (18 mg, 90% yield).

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. custompurified by preparative HPLC

Sources & evidence

ORD record
ord-f1320ab411574bc29f9404241dcfd478
Source dataset
uspto-grants-2006_11
Patent number
US07138423B2

Reaction notes

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