Propylamine → HCID 21884615, compound

HRID 722560Notes

Reaction equation

[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:24][CH2:21][CH2:22][CH3:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

Reactant 2

HCID 7852Propylamine

HCID 21884583HCID 21884583, compound

Product 1

HCID 21884615HCID 21884615, compound

Procedure

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-5-chlorobenzoxazole (263 mg, 0.9 mmol) and propylamine (400 μL, 5.0 mmol) the subtitle compound was obtained (296 mg, 99%). 1H NMR (DMSO) δ 9.33(t, 1H), 9.02(s, 1H), 8.44(dd, 1H), 8.16–8.11(m, 2H), 7.75(dd, 1H), 7.29(d, 1H), 3.67(q, 2H), 1.97(m, 2H), 1.28(t, 3H).

Sources & evidence

ORD record: ord-4d6a91a5d6c14becb265cd90c9750541
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138425B2

Reaction notes

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