Benzo(B)Thiophene-2-Boronic Acid → 2-(3-Nitro-6-propylaminophenyl)-5-(2-benzothiophenyl)benzoxazole

HRID 722658ノート

反応式

HRID 722658 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:14]2[O:15][C:16]3[CH:22]=[CH:21][C:20](Br)=[CH:19][C:17]=3[N:18]=2)[C:7]([NH:10][CH2:11][CH2:12][CH3:13])=[CH:8][CH:9]=1)([O-:3])=[O:2].[S:24]1[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=2[CH:26]=[C:25]1B(O)O>>[N+:1]([C:4]1[CH:5]=[C:6]([C:14]2[O:15][C:16]3[CH:22]=[CH:21][C:20]([C:25]4[S:24][C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=5[CH:26]=4)=[CH:19][C:17]=3[N:18]=2)[C:7]([NH:10][CH2:11][CH2:12][CH3:13])=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

3

反応物 2

HCID 2359Benzo(B)Thiophene-2-Boronic AcidHCID 53038022-(5-bromo-1,3-benzoxazol-2-yl)-4-nitro-N-propylaniline

生成物 1

HCID 218843092-(3-Nitro-6-propylaminophenyl)-5-(2-benzothiophenyl)benzoxazole

実験手順

Prepared by the method of Example 15d), from 2-(3-nitro-6-propylaminophenyl)-5-bromobenzoxazole (400 mg, 1.59 mmol) and benzothiophene-2-boronic acid (283 mg, 1.59 mmol) the subtitle compound was obtained (386 mg, 57%). The product was used directly in the next step without purification.

出典と根拠

ORDレコード
ord-b412c42a15324a1783496237910ec44d
出典データセット
uspto-grants-2006_11
特許番号
US07138425B2

反応ノート

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