Potassium Iodide → HCID 11372474, compound

HRID 722693Notes

Reaction equation

HRID 722693 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]O.Cl[C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][N:10]=1.[I-].[K+]>C(N(CC)CC)C>[N+:15]([C:12]1[CH:13]=[CH:14][C:9]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:10][CH:11]=1)([O-:17])=[O:16]

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 756345-Aminopentan-1-olHCID 783082-Chloro-5-nitropyridine

Product 1

HCID 11372474HCID 11372474, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Synthesis and purification were performed according to the procedure stated in example 152 using reagents 5-aminopentanol (15 mmol), 2-chloro-5-nitropyridine (15 mmol), 5 ml of triethylamine, and catalytic amounts of potassium iodide in the first step. The final product was purified by column chromatography (eluent: ethyl acetate/triethylamine (90/10)). The solvent was removed under reduced pressure. The residue was crystallized with oxalic acid from diethyl ether/ethanol.

Workup

  1. customSynthesis and purification
  2. customThe final product was purified by column chromatography (eluent: ethyl acetate/triethylamine (90/10))
  3. customThe solvent was removed under reduced pressure
  4. customThe residue was crystallized with oxalic acid from diethyl ether/ethanol

Sources & evidence

ORD record
ord-b1eb3ff085b6466793b7ea6a0dbe753d
Source dataset
uspto-grants-2006_11
Patent number
US07138413B1

Reaction notes

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