HCID 86590808, compound → HCID 69706967, compound

HRID 722735Notes

Reaction equation

HRID 722735 reaction equation
[OH:1][CH:2]1[CH:6]([NH:7][C:8]([C@H:10]2[N:15]3[C:16](=[O:31])[C@@H:17]([NH:22][C:23](=[O:30])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:18][CH:19]=[CH:20][CH2:21][C@H:14]3[CH2:13][CH2:12][CH2:11]2)=[O:9])[CH2:5][C:4](=[O:32])[O:3]1>CCOC(C)=O.[Pd]>[OH:1][CH:2]1[CH:6]([NH:7][C:8]([C@H:10]2[N:15]3[C:16](=[O:31])[C@@H:17]([NH:22][C:23](=[O:30])[C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH2:18][CH2:19][CH2:20][CH2:21][C@H:14]3[CH2:13][CH2:12][CH2:11]2)=[O:9])[CH2:5][C:4](=[O:32])[O:3]1

Participants

4

Reactant 1

HCID 86590808HCID 86590808, compound

Product 1

HCID 69706967HCID 69706967, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

(4S,7S,11aR)-7-benzoylamino-6-oxo-1,3,4,6,7,8,11,11a-octahydro-2H-pyrido[1,2-a]azocine-4-carboxylic acid (2-hydroxy-5-oxo-tetrahydrofuran-3-yl)-amide, 46, is dissolved in EtOAc and treated with a catalytic amount of Pd/C. The resulting suspension is stirred at room temperature under a H2 atmosphere for 2 hours. The solution is filtered to remove the catalyst and concentrated in vacuo to afford the desired product

Workup

  1. filtrationThe solution is filtered
  2. customto remove the catalyst
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9997cd836a0a4efaaadfc76b64b7eb3e
Source dataset
uspto-grants-2006_11
Patent number
US07138395B2

Reaction notes

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