Hydrochloric Acid → HCID 86760300, compound

HRID 722827Notes

Reaction equation

HRID 722827 reaction equation
[NH2:1][C@H:2]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[C@@H:3]([NH:5]C(OC(C)(C)C)=O)[CH3:4].[ClH:28]>O1CCOCC1>[ClH:28].[ClH:28].[NH2:5][C@H:3]([C@H:2]([NH2:1])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH3:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58743394HCID 58743394, compound

Product 1

HCID 86760300HCID 86760300, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of N-Boc derivative 96 (22 mg, 0.057 mmol) in dioxane (0.4 mL), anhydrous HCl solution in dioxane (5.3M, 0.43 mL, 2.29 mmol) was added. After stirring at room temperature for 5 h, the solvent was removed in vacuo. The resulting solid was washed with dioxane to obtain dihydrochloride 97 as a white solid (11.5 mg, 56% yield).

Workup

  1. customthe solvent was removed in vacuo
  2. washThe resulting solid was washed with dioxane

Sources & evidence

ORD record
ord-9eb081f3b57b4bf2ace0caad43a73c5a
Source dataset
uspto-grants-2006_11
Patent number
US07138547B2

Reaction notes

Loading…