Methyl Acrylate → HCID 21872624, compound

HRID 723297Notes

Reaction equation

HRID 723297 reaction equation
[C:1]1([C:7]2[NH:8][C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:16]([O:20][CH3:21])(=[O:19])[CH:17]=[CH2:18]>CO>[C:1]1([C:7]2[N:8]([CH2:18][CH2:17][C:16]([O:20][CH3:21])=[O:19])[C:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 7294Methyl AcrylateHCID 128552-Phenylbenzimidazole

Product 1

HCID 21872624HCID 21872624, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 194 g of 2-phenylbenzimidazole, 103 g of methyl acrylate and 500 g of methanol was heated and stirred at 60° C. for 100 hours. The solvent was distilled off in vacuo, followed by purification by column chromatography. There was obtained methyl 3-(2-phenyl-1H-benzimidazol-1-yl)-propionate (yield 60%).

Workup

  1. temperaturewas heated
  2. distillationThe solvent was distilled off in vacuo
  3. customfollowed by purification by column chromatography

Sources & evidence

ORD record
ord-86344f3c682b4fe2bdd97f1a0120b530
Source dataset
uspto-grants-2006_11
Patent number
US07141352B2

Reaction notes

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