Hydrochloric Acid → HCID 21873516, compound

HRID 723316Notes

Reaction equation

HRID 723316 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]3[O:20][CH2:21][S:22](=[O:32])(=[O:31])[N:23]([CH2:24][C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[C:18]=3[CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33].CCOCC>CO>[ClH:33].[CH2:24]([N:23]1[C:18]2[CH:17]=[CH:16][CH:15]=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[C:19]=2[O:20][CH2:21][S:22]1(=[O:32])=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 58743870HCID 58743870, compound

Product 1

HCID 21873516HCID 21873516, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

4-(1-Benzyl-2,2-dioxo-2,3-dihydro-1H-benzo[4,2,1]oxathiazin-5-yl)-piperazine-1-carboxylic acid tert-butyl ester was dissolved in 1 mL methanol and 1 mL of 2N ethanolic HCl was added. The solution is heated at 100° C. for 30 minutes, at which time was added approximately. 2 mL Et2O. On cooling to room temperature, 30 mg of 1-benzyl-5-piperazin-1-yl-1H-benzo[4,2,1]oxathiazine 2,2-dioxide hydrochloride precipitated as a white solid (61%). (M+H)+=360.

Workup

  1. additionwas added approximately
  2. temperatureOn cooling to room temperature
  3. custom30 mg of 1-benzyl-5-piperazin-1-yl-1H-benzo[4,2,1]oxathiazine 2,2-dioxide hydrochloride precipitated as a white solid (61%)

Sources & evidence

ORD record
ord-a5dcaf3bf6d64af5b4c8de5f167243e6
Source dataset
uspto-grants-2006_11
Patent number
US07141562B2

Reaction notes

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