反应详情

A solution of 1-(4-fluoro-3-nitrophenyl)-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one (100 mg) in dimethylformamide (2 ml) was shaken with 2-dimethylaminoethylamine (0.3 ml) at 70° C. for 2 hours. Volatiles were removed and the residue was partitioned between dichloromethane and water. The organic phase was dried and concentrated. The product with the molecular weight of 459.51 (C25H25N5O4); MS (ESI): 460 ([M+H]+), was obtained in this way.

1. customVolatiles were removed
2. customthe residue was partitioned between dichloromethane and water
3. customThe organic phase was dried
4. concentrationconcentrated
5. customMS (ESI): 460 ([M+H]+), was obtained in this way