反应详情

温度

60 °C

Palladium(II) hydroxide (20% on carbon; 0.4 g) was added to a solution of dimethyl-[3-(4-nitrophenoxy)propyl]amine (3.75 g) in ethanol (75 ml) under argon. Then formic acid (4 ml) was added dropwise, during which the reaction mixture heated to 60° C. while evolving much gas. After a reaction time of 90 minutes, the catalyst was filtered off and the filtrate was concentrated. The residue was partitioned between methyl tert-butyl ether and sodium hydroxide solution (2N). The organic phase was dried and concentrated. The product with the molecular weight of 194.28 (C11H18N2O); MS (ESI):195 ([M+H]+), was obtained in this way.

1. filtrationAfter a reaction time of 90 minutes, the catalyst was filtered off
2. concentrationthe filtrate was concentrated
3. customThe residue was partitioned between methyl tert-butyl ether and sodium hydroxide solution (2N)
4. customThe organic phase was dried
5. concentrationconcentrated
6. customMS (ESI):195 ([M+H]+), was obtained in this way