HCID 21873334, compound → HCID 21873414, compound

HRID 723356Notes

Reaction equation

HRID 723356 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][CH2:16][CH:17]([O:20][CH3:21])[O:18][CH3:19])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[OH-].[Pd+2].[OH-]>[CH3:21][O:20][CH:17]([O:18][CH3:19])[CH2:16][NH:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1

Participants

5

Reactant 2

HCID 21873334HCID 21873334, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21873414HCID 21873414, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

Palladium(II) hydroxide (20% on carbon, 0.5 g) was added to a solution of (4-benzyloxyphenyl)-(2,2-dimethoxyethyl)amine (3.5 g) in ethanol (50 mL) under nitrogen. The nitrogen atmosphere was replaced by hydrogen and the mixture was shaken for 3 hours. The catalyst was filtered off and the filtrate was concentrated. The crude product was reacted further without purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe crude product was reacted further without purification

Sources & evidence

ORD record
ord-29d335d8b56e4ccebe5dece31cb7f01a
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Reaction notes

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