Trifluoroacetic acid → HCID 12096894, compound

HRID 723357Notes

Reaction equation

HRID 723357 reaction equation
[CH:1]1([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]([CH2:28][CH:29](OC)OC)[C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([N:23]([CH2:25][CH2:26][OH:27])[CH3:24])=[CH:19][CH:18]=3)=[O:15])=[CH:9][CH:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.FC(F)(F)C(O)=O>CN(C)C=O.O>[CH:1]1([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:28]=[CH:29][N:16]([C:17]4[CH:22]=[CH:21][C:20]([N:23]([CH2:25][CH2:26][OH:27])[CH3:24])=[CH:19][CH:18]=4)[C:14]3=[O:15])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21873429HCID 21873429, compound

Product 1

HCID 12096894HCID 12096894, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of 1-(4-cyclopentyloxyphenyl)-1-(2,2-dimethoxyethyl)-3-{4-[(2-hydroxyethyl)methylamino]phenyl}urea (0.4 g) in dimethyl-formamide (6 mL) was mixed with trifluoroacetic acid (2 mL) and left to stand for 48 hours. The mixture was diluted with water and extracted with ethyl acetate. The organic phase was washed with water and sodium carbonate solution, dried and concentrated. The product with the molecular weight of 393.49 (C23H27N3O3); MS (ESI): 394 ([M+H]+), was obtained in this way.

Workup

  1. waitleft
  2. extractionextracted with ethyl acetate
  3. washThe organic phase was washed with water and sodium carbonate solution
  4. customdried
  5. concentrationconcentrated
  6. customMS (ESI): 394 ([M+H]+), was obtained in this way

Sources & evidence

ORD record
ord-605751eaaa98424499c26161e7081161
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Reaction notes

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