2-(Methylamino)ethanol → 2-(Methyl(4-nitrophenyl)amino)ethan-1-ol

HRID 723358Notes

Reaction equation

HRID 723358 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][NH:12][CH2:13][CH2:14][OH:15]>C(OCC)(=O)C>[CH3:11][N:12]([C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1)[CH2:13][CH2:14][OH:15]

Participants

4

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 9590p-Fluoronitrobenzene

Product 1

HCID 45470772-(Methyl(4-nitrophenyl)amino)ethan-1-ol

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 4-fluoronitrobenzene (20 g) and 2-methylaminoethanol (56 mL) was left to stand for 12 hours and then diluted with ethyl acetate. It was washed with water. The organic phase was dried and concentrated. The product with the molecular weight of 196.21 (C9H12N2O3);

Workup

  1. waitwas left
  2. washIt was washed with water
  3. customThe organic phase was dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-d4179862f6084027901ef93b149140d5
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Reaction notes

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