HCID 9888078, compound → HCID 21873392, compound

HRID 723359Notes

Reaction equation

HRID 723359 reaction equation
[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH:16]=[CH:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[C:13]2=[O:30])=[CH:8][CH:7]=1.[H][H]>C(O)C.[OH-].[Pd+2].[OH-]>[CH3:1][N:2]([CH3:31])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:19][CH:18]=3)[C:13]2=[O:30])=[CH:8][CH:7]=1

Participants

5

Reactant 2

HCID 9888078HCID 9888078, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21873392HCID 21873392, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

Palladium(II) hydroxide (20 mg) was added to a solution of 1-(4-(2-dimethylaminoethoxy)phenyl]-3-(4-phenoxyphenyl)-1,3-dihydroimidazol-2-one (50 mg) in ethanol (5 mL) under nitrogen. The nitrogen atmosphere was replaced by hydrogen and the mixture was shaken for 8 hours. The catalyst was filtered off and the filtrate was concentrated. The product with the molecular weight of 417.51 (C25H27N3O3); MS (ESI): 418 ([M+H]+), was obtained in this way.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated
  3. customMS (ESI): 418 ([M+H]+), was obtained in this way

Sources & evidence

ORD record
ord-5caf65059b3443d883c9831630e02d7c
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Reaction notes

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