反应详情

This was prepared by heating 6-methoxy-quinolin-4-ol (1 g) and phosphorus oxybromide (5 g) in chloroform (40 ml) under reflux for 18 hours. The mixture was cooled, basified with sodium bicarbonate, extracted with 5% methanol-chloroform, and dried (sodium sulfate). The product was chromatographed on silica gel (2-5% methanol-dichloromethane) to afford a solid (0.68 g).

1. customThis was prepared
2. temperatureunder reflux for 18 hours
3. temperatureThe mixture was cooled
4. extractionextracted with 5% methanol-chloroform
5. dry with materialdried (sodium sulfate)
6. customThe product was chromatographed on silica gel (2-5% methanol-dichloromethane)