Diethyl Malonate → 7-hydroxy-2,2-dimethyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

HRID 72377Notes

Reaction equation

HRID 72377 reaction equation
Br.[CH3:2][C:3]1([CH3:9])[CH2:7][NH:6][C:5](=[NH:8])[NH:4]1.[C:10](OCC)(=[O:17])[CH2:11][C:12](OCC)=[O:13].C[O-].[Na+]>>[OH:17][C:10]1[N:8]=[C:5]2[NH:4][C:3]([CH3:9])([CH3:2])[CH2:7][N:6]2[C:12](=[O:13])[CH:11]=1

Participants

4

Reactant 3

HCID 7761Diethyl MalonateHCID 10942334Sodium MethoxideHCID 178419513HCID 178419513, compound

Product 1

HCID 1362693147-hydroxy-2,2-dimethyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one

Procedure

The process is carried out according to the procedure described in stage g of Example 1, using 5 g of 4,4-dimethylimidazolidin-2-ylideneamine hydrobromide, 4 ml of diethyl malonate and 2.8 g of sodium methoxide. 4.5 g of 7-hydroxy-2,2-dimethyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one are thus obtained in the form of a white solid.

Sources & evidence

ORD record
ord-2c312285eb3c4331af3247db26bef229
Source dataset
uspto-grants-2014_09
Patent number
US08828997B2

Reaction notes

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