反应详情

To a solution of anhydrous THF (6.7 mL) was added 5-amino-benzothiazol-2-ylamine (Example 16, 100 mg, 0.61 mmol) and benzoyl isothiocyanate (0.08 mL, 1 equiv). The resulting mixture was stirred at room temperature for 2 hours, after which the solvent was evaporated and the residue was washed with a 1:1 mixture of ether/hexanes (0.164 g, 83%). 1H NMR (DMSO d6) δ: 12.61 (s, 1H), 11.53 (s, 1H), 7.99 (d, 1H, J=3.9 Hz), 7.76 (s, 1H), 7.69–7.65 (m, 2H), 7.59–7.53 (m, 4H), 7.25–7.23 (d, 1H, J=3.9 Hz); MS (ESI) 328.8 (M+1, 100%).

1. customafter which the solvent was evaporated
2. washthe residue was washed with a 1:1 mixture of ether/hexanes (0.164 g, 83%)