反应详情

A suspension of 1,3-dibromobenzene (25.3 g), 4-fluorophenylboronic acid (5.00 g) and 2M aqueous sodium carbonate solution (35.7 ml) in DMF (250 ml) was degassed. Tetrakis(triphenylphosphine)palladium(0) (2.06 g) was added under an argon atmosphere and the mixture was refluxed under heating for 21 h. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate, washed twice with water and washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and distilled under reduced pressure to give the title compound (5.84 g) as a colorless oil.

1. customwas degassed
2. additionTetrakis(triphenylphosphine)palladium(0) (2.06 g) was added under an argon atmosphere
3. temperaturethe mixture was refluxed
4. temperatureunder heating for 21 h
5. additionWater was added to the reaction mixture
6. extractionthe mixture was extracted with ethyl acetate
7. washwashed twice with water
8. washwashed with saturated brine
9. dry with materialdried over anhydrous magnesium sulfate
10. customThe solvent was evaporated under reduced pressure
11. distillationdistilled under reduced pressure