Hydrogen Bromide → HCID 178520414, compound

HRID 724211Notes

Reaction equation

HRID 724211 reaction equation
C([N:20]1[CH:24]=[C:23]([C:25](=[O:28])[CH:26]=[CH2:27])[N:22]=[CH:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[BrH:29].C(OC(C)C)(C)C>C(O)(=O)C>[Br:29][CH2:27][CH2:26][C:25]([C:23]1[N:22]=[CH:21][NH:20][CH:24]=1)=[O:28]

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 7914Diisopropyl EtherHCID 218796192-Propen-1-one, 1-[1-(triphenylmethyl)-1H-imidazol-4-yl]-

Product 1

HCID 178520414HCID 178520414, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Conditions

Temperature
10 °C

Procedure

1-(1-Trityl-1H-imidazol-4-yl)-2-propen-1-one (29.0 g) was dissolved in acetic acid (130 ml) and the mixture was cooled to 10° C. A 25% solution of hydrogen bromide in acetic acid (100 ml) was added and the mixture was stirred at room temperature for 2 h. Isopropyl ether was added to the reaction mixture and the precipitated crystals were collected by filtration and washed with diisopropyl ether to give the title compound (22.3 g) as a pale yellow powder.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-a403f1573a534468a7c9b17fe82ce75d
Source dataset
uspto-grants-2006_11
Patent number
US07141598B2

Reaction notes

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