(4-Methoxyphenyl)boronic acid → 4-(4'-Methoxy-biphenyl-3-yl)-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole

HRID 724451Notes

Reaction equation

HRID 724451 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=3)[O:11][C:12]=2[CH3:13])=[CH:4][CH:3]=1.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1>>[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([C:3]2[CH:2]=[CH:7][CH:6]=[C:5]([C:8]3[N:9]=[C:10]([C:14]4[CH:15]=[CH:16][C:17]([C:20]([F:21])([F:23])[F:22])=[CH:18][CH:19]=4)[O:11][C:12]=3[CH3:13])[CH:4]=2)=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 106912782-[4-(Trifluoromethyl)phenyl]-4-(4-bromophenyl)-5-methyloxazole

Product 1

HCID 99313224-(4'-Methoxy-biphenyl-3-yl)-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole

Procedure

The title compound was prepared from 4-(4-bromo-phenyl)-5-methyl-2-(4-trifluoromethyl-phenyl)-oxazole, and 4-methoxy-benzeneboronic acid in substantially the same manner, as described in Example 1 step c, and was obtained as a white solid, mp 93–94° C.; MS m/e 409 (M+);

Workup

  1. customwas obtained as a white solid, mp 93–94° C.

Sources & evidence

ORD record
ord-7b5eddcb2155406c8525ff68f1bcbcab
Source dataset
uspto-grants-2006_11
Patent number
US07141672B2

Reaction notes

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