Methyl bromoacetate → {3,5-Dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-acetic acid

HRID 724453Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:15]=[CH:14][C:13]([C:16]3[N:17]=[C:18]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=4)[O:19][C:20]=3[CH3:21])=[CH:12][CH:11]=2)[CH:5]=[C:6]([Br:9])[C:7]=1[OH:8].Br[CH2:33][C:34]([O:36]C)=[O:35]>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[CH:12][C:13]([C:16]3[N:17]=[C:18]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:29])([F:31])[F:30])=[CH:24][CH:23]=4)[O:19][C:20]=3[CH3:21])=[CH:14][CH:15]=2)[CH:5]=[C:6]([Br:9])[C:7]=1[O:8][CH2:33][C:34]([OH:36])=[O:35]

Participants

Reactant 2

HCID 60984Methyl bromoacetate

HCID 9915604HCID 9915604, compound

Product 1

HCID 10348783{3,5-Dibromo-4'-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-yloxy}-acetic acid

Procedure

The title compound was prepared from 3,5-dibromo-4′-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-biphenyl-4-ol, and methyl bromoacetate in substantially the same manner, as described in Example 5, and was obtained as an off-white solid, mp 165–166° C.; MS m/e 609 (M+);

Workup

customwas obtained as an off-white solid, mp 165–166° C.

Sources & evidence

ORD record: ord-a8e5e9164fb948ffa719b59eca55cbac
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141672B2

Reaction notes

Loading…