反应详情

A mixture of methyl 2-chloro-5-fluoronicotinate (D69) (199.85 mg, 1.054 mmol) and potassium carbonate (291 mg, 2.108 mmol) in tetrahydrofuran (2 ml) was stirred under N2 nitrogen 15 min at room temperature. N-(4-fluoro-2-methylphenyl)azetidin-3-amine (D55) (190 mg, 1.054 mmol) was added and the resulting mixture was stirred 1 day at room temperature. The residue obtained after solvent evaporation was purified by Biotage SNAP-Si column eluting with a mixture cyclohexane/ethyl acetate from 100/0 to 80/20. Collected fractions after solvent evaporation afforded the title compound (D90)(155 mg)

1. stirringthe resulting mixture was stirred 1 day at room temperature
2. customThe residue obtained
3. customafter solvent evaporation
4. customwas purified by Biotage SNAP-Si column
5. washeluting with a mixture cyclohexane/ethyl acetate from 100/0 to 80/20
6. customCollected fractions after solvent evaporation