Toluene → HCID 69597933, compound

HRID 724589Notes

Reaction equation

HRID 724589 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:26](=[O:28])[NH2:27])[CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[S:20][N:19]([C:21]([CH3:24])([CH3:23])[CH3:22])[C:18](=[O:25])[CH:17]=2)=[CH:12][CH:11]=1)(C)(C)C.C1(C)C=CC=CC=1.[C:37]([OH:43])([C:39]([F:42])([F:41])[F:40])=[O:38]>C(Cl)Cl>[F:40][C:39]([F:42])([F:41])[C:37]([OH:43])=[O:38].[NH2:7][C@@H:8]([CH2:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[S:20][N:19]([C:21]([CH3:23])([CH3:22])[CH3:24])[C:18](=[O:25])[CH:17]=2)=[CH:14][CH:15]=1)[C:26]([NH2:27])=[O:28]

Participants

5

Reactant 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 69598145HCID 69598145, compound

Product 1

HCID 69597933HCID 69597933, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1-G (0.76 g, 1.8 mmol) in 30% TFA in CH2Cl2 (15 mL) was stirred at 25° C. for 2 h. The reaction mixture was concentrated in vacuo to give a solid. The salt was co-evaporated with toluene (2×20 mL) to yield 1-H as a tan solid (quantitative) which was used in the next step without further purification.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customto give a solid
  3. customto yield 1-H as a tan solid (quantitative) which
  4. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-c989f742dbca4732afbf7bbce70ac6ae
Source dataset
uspto-grants-2006_11
Patent number
US07141596B2

Reaction notes

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