Oxalyl chloride → HCID 19710980, compound

HRID 724789Notes

Reaction equation

HRID 724789 reaction equation
[C:1](Cl)(=[O:5])[C:2]([Cl:4])=[O:3].OC1OC[N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:23])([F:22])[F:21])[CH:14]=2)[C:9]1=O>C(Cl)Cl.CN(C=O)C>[Cl:4][CH:2]1[O:3][CH2:9][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][C:20]([F:21])([F:22])[F:23])[CH:14]=2)[C:1]1=[O:5]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 19360779HCID 19360779, compound

Product 1

HCID 19710980HCID 19710980, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Oxalyl chloride (2.7 ml) was added dropwise over 1 min to a stirred solution of 5-hydroxy-3-(3-trifluoromethoxyphenyl)oxazolidin-4-one (8.17 g) in DCM (60 ml) containing DMF (1 drop) at 0° C. The mixture was allowed to warm to room temperature and once gas evolution had stopped the solvent was removed in vacuo to give the sub-title compound (8.5 g) which was used directly in the next step.

Workup

  1. customwas removed in vacuo

Sources & evidence

ORD record
ord-ca072e5e7a3b4cf3829b767194cfd045
Source dataset
uspto-grants-1998_01
Patent number
US05705456

Reaction notes

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