反应详情

50 mg (0.16 mmol) of N-(3-chloro-phenyl)-4-(2-cyano-4-pyridyl)-2-pyrimidineamine are suspended in 2 ml of methanol. 0.58 ml of hydrogen peroxide (30% strength), 0.16 ml of 1-hexene and 11 mg of sodium carbonate are added and the reaction mixture is stirred for 14 hours at RT. The product is isolated by filtration, washed (methanol:water=1:1) and dried at 50° under HV. N-(3-chloro-phenyl)-4-(2-carbamoyl-4-pyridyl)-2-pyrimidineamine is obtained in the form of a yellow powder; m.p. 245°-247°, Rf =0.23 (n-hexane:ethyl acetate=1:1).

1. customThe product is isolated by filtration
2. washwashed (methanol:water=1:1)
3. customdried at 50° under HV