反应详情

To a solution of diphenylacetic acid (20 g, 0.094 mol) in EtOH (70 mL), was added toluene (70 mL). Next, H2SO4 (3 mL) was added dropwise and the reaction mixture was refluxed for 18 h. Then, H2O and EtOAc were added, the layers were separated, and the organic phase was washed with saturated NaHCO3 solution (3×), dried and concentrated to a white solid (23.2 g), which was directly used in the next step as obtained.

1. temperaturethe reaction mixture was refluxed for 18 h
2. customthe layers were separated
3. washthe organic phase was washed with saturated NaHCO3 solution (3×)
4. customdried
5. concentrationconcentrated to a white solid (23.2 g), which
6. customas obtained