反应详情

0.1 mole of D-aspartic acid β-ethyl ester is dissolved in 200 ml of methanol, 0.2 mole of hydroxylamine hydrochloride is then added and the mixture is stirred until complete dissolution occurs. 0.4 mole of triethylamine is added and stirring is continued at room temperature for about 48 hr. The precipitate formed is collected on a filter. This crude product is recrystallized by dissolution in water, then diluted in absolute ethanol. This solution is kept at +4° C. for 12 hr. The crystals are filtered, washed with absolute ethanol and air-dried. This reaction yields 50 to 70% of D-Aspartic acid β-Hydroxamate.

1. stirringstirring
2. customThe precipitate formed
3. customis collected on a filter
4. customThis crude product is recrystallized by dissolution in water
5. additiondiluted in absolute ethanol
6. waitThis solution is kept at +4° C. for 12 hr
7. filtrationThe crystals are filtered
8. washwashed with absolute ethanol
9. customair-dried