HCID 21847197, compound → HCID 21847179, compound

HRID 725294Notes

Reaction equation

HRID 725294 reaction equation
[CH3:1][O:2][C:3]1[C:4]([O:30]S(C2C=CC(C)=CC=2)(=O)=O)=[CH:5][C:6]2[CH2:15][CH2:14][CH:13]([N:16]3C(=O)C4[C:18](=CC=CC=4)[C:17]3=O)[C:12]3[CH2:11][CH2:10][CH2:9][C:8]=3[C:7]=2[C:27]=1[O:28][CH3:29]>O1CCCC1.[Pd]>[CH3:1][O:2][C:3]1[C:4]([OH:30])=[CH:5][C:6]2[CH2:15][CH2:14][CH:13]([NH:16][CH:17]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][CH:27]=3)[CH3:18])[C:12]3[CH2:11][CH2:10][CH2:9][C:8]=3[C:7]=2[C:27]=1[O:28][CH3:29]

Participants

4

Reactant 1

HCID 21847197HCID 21847197, compound

Product 1

HCID 21847179HCID 21847179, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 15 was dissolved in 700 ml of tetrahydrofuran and 2 g of palladium on activated charcoal were added. Hydrogenation (1.2 bar) was carried out for 20 hours and after filtering and evaporating the solvent, 6.9 g of the expected product were obtained which was identical to that of Stage A of Example 15.

Workup

  1. filtrationafter filtering
  2. customevaporating the solvent

Sources & evidence

ORD record
ord-8adc286bcfe0436883b03874f9b11642
Source dataset
uspto-grants-1998_01
Patent number
US05705704

Reaction notes

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