2-Methoxyethylamine → HCID 54038932, compound

HRID 725635Notes

Reaction equation

HRID 725635 reaction equation
CO[C:3](=[O:18])[CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9].[CH3:19][O:20][CH2:21][CH2:22][NH2:23]>C(O)C>[CH3:19][O:20][CH2:21][CH2:22][NH:23][C:3](=[O:18])[CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9]

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 13874704Methyl 4-{[(benzyloxy)carbonyl]amino}butanoate

Product 1

HCID 54038932HCID 54038932, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.02 g of 4-benzyloxycarbonylaminobutyric acid methyl ester are stirred under reflux in 35 ml of ethanol with 15 ml of 2-methoxyethylamine for 5 days. The reaction mixture is concentrated by evaporation and the residue is purified by means of FC (240 g of silica gel, dichloromethane/methanol=95:5). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.33.

Workup

  1. concentrationThe reaction mixture is concentrated by evaporation
  2. customthe residue is purified by means of FC (240 g of silica gel, dichloromethane/methanol=95:5)

Sources & evidence

ORD record
ord-40b375caf74840b78194d222ce973d69
Source dataset
uspto-grants-1998_01
Patent number
US05705658

Reaction notes

Loading…