Aminoacetaldehyde dimethyl acetal → HCID 19708597, compound

HRID 725761Notes

Reaction equation

HRID 725761 reaction equation
[Cl:1][C:2]1[C:3](OS(O)(=O)=O)=[C:4]2[C:9](=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17]([CH:19]1[CH2:21][CH2:20]1)=[O:18])=[C:5]2C.[CH3:28][O:29][CH:30]([O:33][CH3:34])[CH2:31][NH2:32]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([F:13])([F:14])[F:15])[CH:11]=1)[NH:8][C:7](=[O:16])[C:6]([C:17]([CH:19]1[CH2:20][CH2:21]1)=[O:18])=[C:5]2[NH:32][CH2:31][CH:30]([O:33][CH3:34])[O:29][CH3:28]

Participants

4

Reactant 2

HCID 89728Aminoacetaldehyde dimethyl acetalHCID 131720380HCID 131720380, compound

Product 1

HCID 19708597HCID 19708597, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6-Chloro-3-cyclopropanecarbonyl-4-methylsulfoxy-8-trifluormethyl-2-quinolinone (377 mg, 1 mmol) and 2,2-dimethoxyethylamine (105 mg, 1 mmol) were dissolved in tetrahydrofurane (20 ml) and stirred for 24 hr at room temperature. After completion of reaction, solvent was removed under reduced pressure and residue was recrystallized from ethanol to give desired product (335 mg, yield: 80%).

Workup

  1. customAfter completion of reaction, solvent
  2. customwas removed under reduced pressure and residue
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-1290b6993f7c42c987032ad8089f31d3
Source dataset
uspto-grants-1998_01
Patent number
US05707931

Reaction notes

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