3-Azabicyclo[3.2.2]nonane → 3-(4-Methoxy-1-naphthylsulfonyl)-3-azabicyclo[3.2.2]nonane

HRID 725786Notes

Reaction equation

HRID 725786 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([S:13](Cl)(=[O:15])=[O:14])=[CH:5][CH:4]=1.[CH:17]12[CH2:25][CH2:24][CH:21]([CH2:22][CH2:23]1)[CH2:20][NH:19][CH2:18]2.CCN(C(C)C)C(C)C>>[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([S:13]([N:19]2[CH2:20][CH:21]3[CH2:24][CH2:25][CH:17]([CH2:23][CH2:22]3)[CH2:18]2)(=[O:15])=[O:14])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 92403-Azabicyclo[3.2.2]nonaneHCID 81531DiisopropylethylamineHCID 167755014-Methoxynaphthalene-1-sulfonyl chloride

Product 1

HCID 197087123-(4-Methoxy-1-naphthylsulfonyl)-3-azabicyclo[3.2.2]nonane

Procedure

The title compound was prepared by reacting 4-methoxy-1-naphthalenesulfonyl chloride (0.25 g) with 3-azabicyclo[3.2.2]nonane (0.12 g) in the presence of DIEA (0.16 g) using a procedure similar to that used in Example 5. Yield: 0.24 g, mp 167.7°-169.5° C. (soften 166.1° C.).

Workup

  1. customYield: 0.24 g, mp 167.7°-169.5° C. (soften 166.1° C.)

Sources & evidence

ORD record
ord-31bc1180cd57475cb31c7564cb470924
Source dataset
uspto-grants-1998_01
Patent number
US05707985

Reaction notes

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