反应详情

D 4-[2-(2-Fluorobenzylidaneamino)acetyl]morpholine can be prepared as described in Example 2D, but from 5.3 cm3 of 2-fluorobenzaldehyde, 9.1 g of 4-(2-aminoacetyl)morpholine hydrochloride, 6 g of 4 Å seive and 7 cm3 of triethylamine in 150 cm3 of dichloromethane. After treatment, there are obtained 12 g of 4-[2-(2-fluorobenzylideneamino)acetyl]morpholine in the form of an oil used as is in the subsequent syntheses.