Triethylamine → HCID 19709590, compound

HRID 725879Notes

Reaction equation

HRID 725879 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:11][CH2:12][C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14].C(N(CC)CC)C>ClCCl>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[N:11][CH2:12][C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 67970o-FluorobenzaldehydeHCID 122918142-Amino-1-(morpholin-4-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 19709590HCID 19709590, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

D 4-[2-(2-Fluorobenzylidaneamino)acetyl]morpholine can be prepared as described in Example 2D, but from 5.3 cm3 of 2-fluorobenzaldehyde, 9.1 g of 4-(2-aminoacetyl)morpholine hydrochloride, 6 g of 4 Å seive and 7 cm3 of triethylamine in 150 cm3 of dichloromethane. After treatment, there are obtained 12 g of 4-[2-(2-fluorobenzylideneamino)acetyl]morpholine in the form of an oil used as is in the subsequent syntheses.

Sources & evidence

ORD record
ord-f3079257dfc8430aa21b28126e294f43
Source dataset
uspto-grants-1998_01
Patent number
US05707991

Reaction notes

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