Potassium Iodide → HCID 22733883, compound
Reaction equation
O=[CH:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:6]([O:7][CH3:8])[C:4]=1[OH:5].Cl.[N:13]1[CH:18]=[CH:17][C:16]([CH2:19]Cl)=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>CN(C=O)C>[CH3:8][O:7][C:6]1[C:4]2[O:5][C:19]([C:16]3[CH:17]=[CH:18][N:13]=[CH:14][CH:15]=3)=[CH:2][C:3]=2[CH:11]=[CH:10][CH:9]=1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 150 °C
Procedure
To a solution of o-vanillin (6.0 g) and 4-picolylchloride hydrochloride (6.6 g) in DMF (70 ml) was added potassium carbonate (20.0 g) and potassium iodide (2.0 g). The mixture was stirred vigorously for 8 hours at 150° C. The mixture was filtered hot and the filter cake was washed with ethyl acetate. The organic phases were combined and concentrated in vacuo to a volume of about 10 ml, poured into water and extracted twice with ethyl acetate. The combined organic layers were washed with water, dried (Na2SO4) and concentrated in vacuo. Flash chromatography (silica gel, eluting with 1:2 heptane:ethyl acetate) afforded 2.5 g of the product, which was crystallized from heptane/ethyl acetate, m.p. 140°-141° C.
Workup
- filtrationThe mixture was filtered hot
- washthe filter cake was washed with ethyl acetate
- concentrationconcentrated in vacuo to a volume of about 10 ml
- additionpoured into water
- extractionextracted twice with ethyl acetate
- washThe combined organic layers were washed with water
- dry with materialdried (Na2SO4)
- concentrationconcentrated in vacuo
- washFlash chromatography (silica gel, eluting with 1:2 heptane:ethyl acetate)
Sources & evidence
- ORD record
- ord-da54e5af89634899b9b68b4d656d3fbd
- Source dataset
- uspto-grants-1998_01
- Patent number
- US05708007
Reaction notes
Loading…