1-triphenylmethyl-4-[2-(4-trifluoromethylphenoxy)ethyl]-1H-imidazole → HCID 178506221, compound

HRID 726263Notes

Reaction equation

HRID 726263 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][O:15][C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)[N:10]=[CH:9]2)C=CC=CC=1>O1CCCC1.Cl>[F:25][C:22]([F:23])([F:24])[C:19]1[CH:20]=[CH:21][C:16]([O:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)=[CH:17][CH:18]=1

Participants

4

Reactant 1

HCID 107439231-triphenylmethyl-4-[2-(4-trifluoromethylphenoxy)ethyl]-1H-imidazole

Product 1

HCID 178506221HCID 178506221, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 640 mg (1.28 mmol) of 1-triphenylmethyl-4-[2-(4-trifluoromethylphenoxy)ethyl]-1H-imidazole in 2 ml of tetrahydrofuran and 5 ml of 2N hydrochloric acid is heated at 70° C. for 2 hours. The tetrahydrofuran is then evaporated under reduced pressure and the residue extracted with diethyl ether. The aqueous solution is basified with potassium carbonate and the white solid is filtered and washed 3 times with water to give the title compound, M.p.: 105°-109° C.

Workup

  1. customThe tetrahydrofuran is then evaporated under reduced pressure
  2. extractionthe residue extracted with diethyl ether
  3. filtrationthe white solid is filtered
  4. washwashed 3 times with water

Sources & evidence

ORD record
ord-ab0787d6f51340fca9fb41d2840677ec
Source dataset
uspto-grants-1998_01
Patent number
US05708171

Reaction notes

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