1-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole → HCID 178505893, compound

HRID 726272Notes

Reaction equation

HRID 726272 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][O:16][C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)[N:10]=[CH:9]2)C=CC=CC=1>O1CCCC1.Cl>[F:23][C:20]1[CH:19]=[CH:18][C:17]([O:16][CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)=[CH:22][CH:21]=1

Participants

4

Reactant 1

HCID 106001421-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole

Product 1

HCID 178505893HCID 178505893, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A solution of 147 mg (0.4 mmol) of 1-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole in 1 ml of tetrahydrofuran and 2 ml of 2N hydrochloric acid is heated at 70° C. for 2 hours. The tetrahydrofuran is then evaporated under reduced pressure. The aqueous solution is filtered and basified with potassium bicarbonate. The product is extracted with chloroform and dried over magnesium sulphate. The solvent is evaporated under reduced pressure to give the title compound in the form of a white solid, M.p.: 135°-137° C.

Workup

  1. customThe tetrahydrofuran is then evaporated under reduced pressure
  2. filtrationThe aqueous solution is filtered
  3. extractionThe product is extracted with chloroform
  4. dry with materialdried over magnesium sulphate
  5. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-fb9f0f5acd934023adf2128621ed85b1
Source dataset
uspto-grants-1998_01
Patent number
US05708171

Reaction notes

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