反应详情

A solution of 147 mg (0.4 mmol) of 1-triphenylmethyl-4-[3-(4-fluorophenoxy)propyl]-1H-imidazole in 1 ml of tetrahydrofuran and 2 ml of 2N hydrochloric acid is heated at 70° C. for 2 hours. The tetrahydrofuran is then evaporated under reduced pressure. The aqueous solution is filtered and basified with potassium bicarbonate. The product is extracted with chloroform and dried over magnesium sulphate. The solvent is evaporated under reduced pressure to give the title compound in the form of a white solid, M.p.: 135°-137° C.

1. customThe tetrahydrofuran is then evaporated under reduced pressure
2. filtrationThe aqueous solution is filtered
3. extractionThe product is extracted with chloroform
4. dry with materialdried over magnesium sulphate
5. customThe solvent is evaporated under reduced pressure