反应详情

Methyl 6,7-dichloro-2-hydroxyquinoline-3-carboxylate (2.72 g, 10 mmol) was added in small portions to a stirred solution of DIBAL (1M in hexane, 25 ml, 25 mmol) in tetrahydrofuran (25 ml) under nitrogen at 25°-30° C. The mixture was stirred at ambient temperature for 0.5 h and then quenched with an excess of 20% HCl at 5°-10° C. The precipitate was collected and washed with water, tetrahydrofuran and ethyl ether to give 2.12 g of 6,7-dichloro-2-hydroxyquinoline-3-methanol.

1. customquenched with an excess of 20% HCl at 5°-10° C
2. customThe precipitate was collected
3. washwashed with water, tetrahydrofuran and ethyl ether