反应详情

1,2,3,4-Tetrahydroquinolin-4-one (2.00 g) and 114 mg of p-toluenesulfonic acid were dissolved in 30 ml of acetic acid isopropenyl ether, and the solution was heated under reflux for 2 days simultaneously evaporating acetic acid. Then, saturated sodium bicarbonate aqueous solution was added and the mixture was extracted with ethyl acetate, followed by drying on anhydrous magnesium sulfate. After evaporating the solvent, the resulting residue was crystallized from chloroform-diethyl ether-hexane to obtain 518 mg of 4-acetoxy-1-tosyl-1,2-dihydroquinoline.

1. temperaturethe solution was heated
2. extractionthe mixture was extracted with ethyl acetate
3. dry with materialby drying on anhydrous magnesium sulfate
4. customAfter evaporating the solvent
5. customthe resulting residue was crystallized from chloroform-diethyl ether-hexane