反应详情

Piperazine (1.2 g, 13.77 mM) was heated with 2-chloro-5-(trifluoromethyl)pyridine (0.5 g, 2.75 mmol) in THF (2 mL) for 2 hours. Subsequently the reaction mixture was poured onto crushed ice and extracted with ethyl acetate. The organic layer was washed with sodium bicarbonate and evaporated to furnish the required product.

1. additionSubsequently the reaction mixture was poured
2. customonto crushed ice
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with sodium bicarbonate
5. customevaporated