2-Hydrazinoethanol → HCID 19704697, compound

HRID 726943Notes

Reaction equation

HRID 726943 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][NH2:5].C(N(CC)CC)C.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=1[N:21]=[C:22]=[S:23]>C(Cl)Cl>[NH2:5][N:4]([CH2:3][CH2:2][OH:1])[C:22]([NH:21][C:15]1[CH:16]=[CH:17][C:18]([Cl:20])=[CH:19][C:14]=1[Cl:13])=[S:23]

Participants

5

Reactant 3

HCID 80172-HydrazinoethanolHCID 8471TriethylamineHCID 810662,4-Dichloro-1-isothiocyanatobenzene

Product 1

HCID 19704697HCID 19704697, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

7.61 g (0.10 mol) 2-hydroxyethylhydrazine was dissolved in 100 mL methylene chloride at 0°-5° C. After dropwise addition of 10.2 g (0.10 tool) triethylamine, 20.4 g (0.10 mol) 2,4-dichlorophenylisothiocyanate dissolved in 70 mL methylene chloride was added over a period of 4 h. The reaction mixture was left to warm up to room temperature, stirred for a further 2 h, the precipitate filtered off, washed with methylene chloride and the desired compound isolated.

Workup

  1. additionwas added over a period of 4 h
  2. waitThe reaction mixture was left
  3. filtrationthe precipitate filtered off
  4. washwashed with methylene chloride

Sources & evidence

ORD record
ord-a65fcdd4358340f9879c4692dede1407
Source dataset
uspto-grants-1998_01
Patent number
US05712225

Reaction notes

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