Sodium Cyanide → 2,4-Diamino-5-(2,4-dichlorophenyl)-6-cyanomethyl-pyrimidine

HRID 727073Notes

Reaction equation

HRID 727073 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])=[C:4]([CH2:17]Br)[N:3]=1.[C-:19]#[N:20].[Na+]>CN(C=O)C>[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[C:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=2[Cl:16])=[C:4]([CH2:17][C:19]#[N:20])[N:3]=1

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 19705067HCID 19705067, compound

Product 1

HCID 197051112,4-Diamino-5-(2,4-dichlorophenyl)-6-cyanomethyl-pyrimidine

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared from 2,4-diamino-5-(2,4-dichlorophenyl)-6-bromomethyl-pyrimidine (Example 53) by reaction with sodium cyanide in DMF at room temperature, mp. 249°-251° C.

Sources & evidence

ORD record
ord-e0c17b21b5fb4852b7c8579b45053480
Source dataset
uspto-grants-1998_01
Patent number
US05712276

Reaction notes

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