Chlorotrimethylsilane → HCID 19705234, compound

HRID 727181Notes

Reaction equation

HRID 727181 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8](O)([CH3:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Br-:12].[Li+].C[Si](Cl)(C)C>C(#N)C>[Br:12][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 82050Lithium BromideHCID 593110Benzenemethanol, 3-chloro-.alpha.,.alpha.-dimethyl-

Product 1

HCID 19705234HCID 19705234, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

This compound is prepared in a manner analogous to that of Step A of Example 5, using 8.5 grams (0.05 mole) of 2-(3-chlorophenyl)propan-2-ol, 8.7 grams (0.1 mole) of lithium bromide, and 13.5 grams (0.125 mole) of trimethylsilyl chloride in 100 mL of acetonitrile, yielding 2-bromo-2-(3-chlorophenyl)propane.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step A of Example 5

Sources & evidence

ORD record
ord-b54c55974a5c42bb8a03d7cd5eecabf8
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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