Sodium hydride → HCID 19705202, compound

HRID 727200Notes

Reaction equation

HRID 727200 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([OH:11])[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.[F:12][C:13]([F:23])([F:22])[C:14]1[CH:15]=[C:16]([CH2:20]Br)[CH:17]=[CH:18][CH:19]=1.[H-].[Na+]>C1(C)C=CC=CC=1>[F:12][C:13]([F:22])([F:23])[C:14]1[CH:15]=[C:16]([CH2:20][O:11][CH:8]2[CH2:9][CH2:10][C:5]3([O:4][CH2:3][CH2:2][O:1]3)[CH2:6][CH2:7]2)[CH:17]=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 1230611-(Bromomethyl)-3-(trifluoromethyl)benzeneHCID 5673521,4-Dioxaspiro(4.5)decan-8-ol

Product 1

HCID 19705202HCID 19705202, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This compound is prepared in a manner analogous to that of Step D of Example 9, using 4.7 grams (0.030 mole) of 1,4-dioxaspiro[4.5]decan-8-ol (prepared as in Step B of Example 8), 7.2 grams (0.030 mole) of 3-trifluoromethylphenylmethyl bromide, and 1.3 grams (0.033 mole) of sodium hydride (60% in mineral oil) in 60 mL of toluene, yielding 8-(3-trifluoromethyl phenyl methoxy)-1,4-dioxaspiro[4.5]decane.

Workup

  1. customThis compound is prepared in a manner analogous to that of Step D of Example 9

Sources & evidence

ORD record
ord-d98ef5b0948f487b8cffad229168a104
Source dataset
uspto-grants-1998_01
Patent number
US05712281

Reaction notes

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