Hydrochloric Acid → HCID 22105771, compound

HRID 727228Notes

Reaction equation

HRID 727228 reaction equation
[OH-].[Li+].[CH3:3][C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([NH:11][C:12]([C:14]2[C:15]([C:20]([O:22]CC)=[O:21])=[N:16][O:17][C:18]=2[CH3:19])=[O:13])[CH:5]=1.Cl>O.CO>[CH3:3][C:4]1[CH:9]=[C:8]([CH3:10])[N:7]=[C:6]([NH:11][C:12]([C:14]2[C:15]([C:20]([OH:22])=[O:21])=[N:16][O:17][C:18]=2[CH3:19])=[O:13])[CH:5]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 2764035HCID 2764035, compound

Product 1

HCID 22105771HCID 22105771, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 0.27 g (11.5 mmol) of lithium hydroxide in 3 ml of water and 15 ml of methanol is cooled to -15° C. 1.5 g (5.19 mmol) of the product obtained in Example 96 are added slowly thereto with stirring. The stirring is continued for one hour. The mixture is acidified with dilute hydrochloric acid solution. The temperature is allowed to rise to 0° C. and stirring is continued for 30 min. The mixture is filtered and the title product is collected in the form of a white powder which is washed with t-butyl methyl ether.

Workup

  1. customto rise to 0° C.
  2. stirringstirring
  3. waitis continued for 30 min
  4. filtrationThe mixture is filtered
  5. customthe title product is collected in the form of a white powder which
  6. washis washed with t-butyl methyl ether

Sources & evidence

ORD record
ord-7b88be6c9dd9452bb36c329a081699a2
Source dataset
uspto-grants-1998_01
Patent number
US05712294

Reaction notes

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