反应详情

温度

50 °C

To a solution of sodium (230 mg, 10 mmol) in 1-pentanol (20 ml) was added 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (490 mg, 2.5 mmol). The mixture was stirred at 50° C. for 3 h and evaporated. The residue was dissolved in water and extracted with methylene chloride. The combined organic phases were dried and evaporated to give the wanted compound.

1. customevaporated
2. dissolutionThe residue was dissolved in water
3. extractionextracted with methylene chloride
4. customThe combined organic phases were dried
5. customevaporated
6. customto give the wanted compound